Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.

Nicorandil is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).

Dibucaine hydrochloridel (盐酸地布卡因) is a local anesthetics.

Ranolazine dihydrochloride is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.

Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.

Amiloride hydrochloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).

Proparacaine hydrochloridel is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.