Product Name

Procainamide HCl

General description

Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.   

Synonym

4-amino-N-[2-(diethylamino)ethyl]benzamide; hydrochloride

Purity

≥99.0%(HPLC)

CAS Number

614-39-1

Formula

C¹³H²²ClN³O

Molecular Weight

271.789

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

≥45mg/ml

≥45mg/ml

≥45mg/ml

l  Biological Information

Biochem/Physiol  Actions

Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K₊ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not  for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov