l General Information |
Product Name | Amiloride HCl |
General description | Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM). |
Synonym | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; hydrochloride |
Purity | ≥98.0%(HPLC) | CAS Number | 2016-88-8 |
Formula | C6H9Cl2N7O | Molecular Weight | 266.086 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Pale yellow solid |
Solubility(25°C) | DMSO | ≥45mg/ml |
Ethanol | ~5mg/ml |
Water | ~5mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Amiloride Hydrochloride is the hydrochloride salt of amiloride, a synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not
for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
