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Image Product # Product Name Description Operation
  • DNA Ligase from T4-infected Escherichia coli
    TS0368

    Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo).

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  • DNA Ligase from T4-infected Escherichia coli
    TS0369

    Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0370

    GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0371

    Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0372

    Silmitasertib is a potent and selective inhibitor of CK2 (casein kinase 2).

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  • DNA Ligase from T4-infected Escherichia coli
    TS0875

    Sonidegib (Erismodegib, NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.

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  • DNA Ligase from T4-infected Escherichia coli
    TS0878

    Taladegib (LY2940680) binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling.

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  • DNA Ligase from T4-infected Escherichia coli
    TS1150

    PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.

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