Product Name

Smoothened Agonist (SAG) HCl

General description

Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist.

Synonym

3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide; hydrochloride

Purity

≥98.0%(HPLC)

CAS Number

912545-86-9(free base)

Formula

C²⁸H²⁹Cl²N³OS

Molecular Weight

526.52

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥50mg/mL(warmed)

Ethanol

≥35mg/mL(warmed)

Water

≥50mg/mL

l  Biological Information

Biochem/Physiol  Actions

Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov