Product Name

Silmitasertib (CX-4945)

General description

Silmitasertib is a potent and selective inhibitor of CK2 (casein kinase 2).

Synonym

5-(3-chloroanilino)benzo[c][2,6]naphthyridine-8-carboxylic acid

Purity

≥98.0%(HPLC)

CAS Number

1009820-21-6

Formula

C¹⁹H¹²ClN³O²

Molecular Weight

349.77

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25℃)

DMSO

≥15mg/mL

Ethanol

Insoluble

Water

Insoluble

l  Biological Information

Biochem/Physiol  Actions

Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay).

l  Storage

Storage temp.

-20℃

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov