l General Information |
Product Name | Cyclopamine |
General description | Cyclopamine is a specific Hedgehog (Hh)
signaling pathway antagonist of Smoothened (Smo). |
Synonym | 11-deoxojervine |
Purity | ≥98.0%(HPLC) | CAS Number | 4449-51-8 |
Formula | C27H41NO2 | Molecular Weight | 411.62 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25℃) | DMSO | Insoluble |
Ethanol | Slightly soluble |
DMF | ≥5mg/mL(warmed) |
l Biological Information |
Biochem/Physiol
Actions | Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM in TM3Hh12 cells. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
