1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme. Suicide inhibitor of cytochrome P450 and chloroperoxidase.
Atreleuton is a reversible 5-lipoxygenase inhibitor.
AUDA is a potent inhibitor of soluble epoxide hydrolase.
TPPU is a potent sEH inhibitor (IC50 = 3.7 nM) that has been shown to have very favorable PK attributes in cynomolgus monkeys.
TVB-3166 is a cell-permeable pyrrazole derivative.
Slow reacting substance of anaphylaxis (SRS-A). Potent bronchoconstrictor and mediator of asthmatic and inflammatory processes. Increases cytosolic free Ca2+ in epithelial cells.
Slow reacting substance of anaphylaxis (SRS-A).
BML-111 is an analog of the naturally occurring eicosanoid Lipoxin A4.