l General Information |
Product Name | AUDA |
Gennral description | AUDA is a potent inhibitor of soluble epoxide hydrolase. |
Synonym | 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid |
Purity | ≥98.0%(HPLC) | CAS Number | 479413-70-2 |
Formula | C23H40N2O3 | Molecular Weight | 392.58 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | white to beige solid |
Solubility | DMSO | ≥10mg/mL(at warmed to 60 °C) |
l Biological Information |
Biochem/Physiol Actions |
AUDA is a potent inhibitor of soluble epoxide hydrolase. Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia. |
Application | AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
