l General Information |
Product Name | 1-Aminobenzotriazole |
General description | 1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme. |
Synonym | 1-Benzotriazolamine, ABT |
Purity | ≥98%(TLC) | CAS Number | 1614-12-6 |
Formula | C6H6N4 | Molecular Weight | 134.14 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Faint Yellow to Yellow-Tan solid |
Solubility(25℃) | Ethanol | ≥35mg/mL |
l Biological Information |
Biochem/Physiol Actions | Suicide inhibitor of cytochrome P450 and chloroperoxidase. |
Application | 1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats[2] It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol. |
l Storage |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
