Azoramide is a small-molecule modulator of the unfolded protein response (UPR) that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.
HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket.
Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.
Tenovin-3 is a p53 activator.
NQDI 1 is an inhibitor of ASK1(apoptosis signal-regulating kinase 1), which attenuates acute ischemic renal injury by modulating oxidative stress and cell death.
Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.
GW4869 is a neutral, noncompetitive inhibitor of sphingomyelinase (Smase).
CID5721353 is a BCL6 inhibitor.