l General Information |
Product Name | GW4869 |
General description | GW4869 is a neutral, noncompetitive inhibitor of sphingomyelinase (Smase). |
Synonym | (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro 1H-imidazol-2-yl)phenyl]prop-2-enamide; dihydrochloride; GW 4869; GW-4869 |
Purity | ≥95.0%(HPLC) | CAS Number | 6823-69-4 |
Formula | C30H28N6O2·2HCl·XH2O | Molecular Weight | 577.5 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Pale yellow solid |
Solubility(25℃) | DMSO | Insoluble |
Ethanol | Insoluble |
Water | Insoluble |
l Biological Information |
Biochem/Physiol Actions | GW4869 is a neutral, noncompetitive inhibitor of sphingomyelinase (IC50 = 1 μM). It is selective for N-Smase, and does not inhibit acid SMase at up to at least 150 μM. |
l Packaging & Storage |
Packaging | 5mg; 10mg |
Storage temp. | -20℃ |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
