Product Name

Azoramide

General description

Azoramide is a small-molecule modulator of the unfolded protein response (UPR) that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.

Synonym

N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide; AK163919

Purity

≥98%(HPLC)

CAS Number

932986-18-0

Formula

C¹⁵H¹⁷ClN²OS

Molecular Weight

308.824

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Pale yellow solid

Solubility(25℃)

DMSO

≥50mg/mL

Ethanol

≥50mg/mL

Water

Insoluble

l  Biological Information

Biochem/Physiol   Actions

Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide improves endoplasmic reticulum (ER) protein-folding ability and stimulates the of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress.

l  Packaging & Storage

Packaging

10mg; 50mg; 250mg

Storage temp.

-20℃

l  Precautions and Disclaimer

This   product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov