WS3 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
WS6 is a β cell proliferation inducer via modulation of Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.
Omaveloxolone (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling.
AZD3264 is a novel IKK2 inhibitor.
MRT67307 is a potent and dual IKK and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively.
GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.
GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.