SKI II is a highly selective and non ATP-competitive?sphingosine kinase (SphK)?inhibitor with?IC50?of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.

BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.    

HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.  

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.  

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM.

Ozanimod (RPC1063) is a selective oral S1P Receptor 1 modulator.