Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia-reperfusion injury and cerebral ischemia.
Seratrodast is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist with anti-asthmatic activity.
Pranlukast is a subtype specific CysLT1 receptor antagonist.
Cloprostenol is a potent FP prostanoid receptor agonist.
Thromboxane receptor agonist.
DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP1 and EP2 prostanoid receptors.
Selective thromboxane A2 receptor antagonist
Iloprost is a potent prostacyclin PGI2 analog that binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors.