Iguratimod is a small molecule compound with anti-inflammatory and immunomodulatory actions and used for the treatment of rheumatoid arthritis.

Tiaprofenic acid is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain.

Deracoxib is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).

Motolimod (VTX-2337) is a selective and potent Toll-like receptor (TLR) 8 agonist with EC50 of 100 nM, > 50-fold selectivity over TLR7.

PF-04418948 is a potent and selective prostaglandin EP receptor antagonist with IC50 of 16 nM.

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

MI-2 (MALT1 inhibitor) is an irreversible MALT1 inhibitor with IC50 of 5.84 μM.  

VGX-1027 is an orally active immunomodulator.