BG45 is a class I HDAC inhibitor with IC50 of 289 nM, 2.0 nM, 2.2 nM and >20 nM for HDAC3, HDAC1, HDAC2, and HDAC6 in cell-free assays, respectively.
BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.
BRD73954 is a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
6-thio-dG is a nucleoside analog and telomerase substrate.
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis.
CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.