Product Name

Isoliensinine

General description

Isoliensinine is an alkaloid produced by the edible plant Nelumbo nucifera. It possesses anti-cancer, anti-fibrosis, anti-proliferative, antioxidant, and anti-inflammatory activities.

Purity

≥95.0%(HPLC)

CAS Number

6817-41-0

Formula

C³⁷H⁴²N²O⁶

Molecular Weight

610.73918

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥50mg/mL

l  Biological Information

Biochem/Physiol  Actions

Isoliensinine possesses a significant inhibitory effect on bleomycin (BLM)-induced pulmonary fibrosis, probably due to its antioxidant and/or anti-inflammatory activities and inhibitory overexpressing tumor necrosis factor alpha (TNF-alpha) and transforming growth factor beta 1 (TGF-beta (1)) induced by BLM.

Isoliensinine possesses an anti-proliferative effect on angiotensin II-induced proliferation of porcine coronary arterial smooth muscle cells, which is related to the decrease of the over of growth factors Platelet-derived growth factor (PDGF)-beta, basic fibroblast growth factor (bFGF), proto-oncogene c-fos, c-myc and hsp70.

Isoliensinine can induce apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation, it exerts anti-cancer activity.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov