l General Information |
Product Name | PK11007 |
General description | PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR. |
Synonym | 5-chloro-2-methylsulfonylpyrimidine-4-carboxylic
acid |
Purity | ≥98.5%(HPLC) | CAS Number | 38275-34-2 |
Formula | C6H5ClN2O4S | Molecular Weight | 236.63 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥35mg/mL |
Ethanol | ≥15mg/mL |
Water | ≥35mg/mL |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
