Product Name

2-D08

General description

2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays.

Synonym

2',3',4'-trihydroxy flavone; 2-(2,3,4-trihydroxyphenyl)chromen-4-one

Purity

≥98.5%(HPLC)

CAS Number

144707-18-6

Formula

C¹⁵H¹⁰O⁵

Molecular Weight

270.24

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Beige Solid

Solubility(25°C)

DMSO

≥45mg/mL

Ethanol

Insoluble

Water

Very slightly soluble

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov