Product Name

Chk2 Inhibitor II (BML-277)

General description

Chk2 Inhibitor II (BML-277) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM. It is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases.

Synonym

IN1500; 2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide

Purity

≥98.5%(HPLC)

CAS Number

516480-79-8

Formula

C²⁰H¹⁴ClN³O²

Molecular Weight

363.8

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Off-White to Tan Solid

Solubility(25°C)

DMSO

≥50mg/mL

Ethanol

≥15mg/mL

Water

Very slightly soluble

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov