Product Name

ONO-4059 hydrochloride

General description

ONO-4059 hydrochloride is highly potent and selective BTK inhibitor with an IC50 of 2.2 nM.

Synonym

GS-4059 hydrochloride 

Purity

≥98.5%(HPLC)

CAS Number

1439901-97-9

Formula

C²⁵H²³ClN⁶O³

Molecular Weight

490.94

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥50mg/mL

Ethanol

Slightly soluble

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Tirabrutinib Hydrochloride is the hydrochloride salt form of tirabrutinib, an orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, tirabrutinib covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov