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Home > Products > Small molecule > GPCR & G Protein > Sotagliflozin (LX4211)

Sotagliflozin (LX4211)

Product #: TS3374
Image SKU-Pack Size Stock Price($) Quantity
  • TS3374-2MG

    In-stock

    102

    - +

    TS3374-5MG

    In-stock

    186

    - +

    TS3374-10MG

    In-stock

    300

    - +

    TS3374-25MG

    In-stock

    600

    - +

Documents

Details

l  General Information

Product Name

Sotagliflozin

General description

Sotagliflozin is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively.

Synonym

LX4211

Purity

≥98.5%(HPLC)

CAS Number

1018899-04-1

Formula

C21H25ClO5S

Molecular Weight

424.94

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥50mg/mL

Ethanol

≥5mg/mL

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Sotagliflozin is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. Upon oral administration, sotagliflozin binds to and blocks both SGLT1 in the gastrointestinal (GI) tract and SGLT2 in the kidneys, thereby suppressing the absorption of glucose from the GI tract and the reabsorption of glucose by the proximal tubule into the bloodstream, respectively. This decreases glucose uptake and enhances the urinary excretion of glucose, which lowers and/or normalizes blood glucose levels. SGLT1 is the primary transporter responsible for glucose absorption from the GI tract. SGLT2, a transport protein exclusively expressed in the proximal renal tubules, mediates approximately 90% of renal glucose reabsorption from tubular fluid.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov

 

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