l General Information |
Product Name | Napabucasin |
General description | Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor. |
Synonym | BBI608; 2-acetylbenzo[f][1]benzofuran-4,9-dione |
Purity | ≥98.5%(HPLC) | CAS Number | 83280-65-3 |
Formula | C14H8O4 | Molecular Weight | 240.21 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Brown Solid |
Solubility(25°C) | DMSO | ≥5mg/mL |
Ethanol | Insoluble |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Napabucasin is an orally available cancer cell stemness inhibitor with potential antineoplastic activity. Even though the exact target has yet to be fully elucidated, napabucasin appears to target and inhibit multiple pathways involved in cancer cell stemness. This may ultimately inhibit cancer stemness cell (CSC) growth as well as heterogeneous cancer cell growth. CSCs, self-replicating cells that are able to differentiate into heterogeneous cancer cells, appear to be responsible for the malignant growth, recurrence and resistance to conventional chemotherapies. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
