Product Name

3PO

General description

3PO is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD₊, and NADH.

Synonym

(E)-3-pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one 

Purity

≥98.5%(HPLC)

CAS Number

18550-98-6

Formula

C¹³H¹⁰N²O

Molecular Weight

210.23

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to beige Solid

Solubility(25°C)

DMSO

≥35mg/ml

Ethanol

≥35mg/ml

Water

Very slightly soluble

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov