l General Information |
Product Name | Lomitapide |
General description | Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia. |
Synonym | BMS-201038; Juxtapid; Lojuxta; AEGR-733 |
Purity | ≥98.5%(HPLC) | CAS Number | 182431-12-5 |
Formula | C39H37F6N3O2 | Molecular Weight | 692.71 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to beige Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | ≥50mg/ml |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Lomitapide is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein. Inhibition of MTP by lomitapide blocks transfer of lipid to apo-B, and as a result emerging apo-B is destroyed and lipoprotein secretion is inhibited. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
