l General Information |
Product Name | Tasisulam |
General description | Tasisulam is an antitumor agent and an apoptosis inducer via the intrinsic pathway. |
Synonym | LY573636; N-(5-bromothiophen-2-yl)sulfonyl-2,4-dichlorobenzamide |
Purity | ≥98.5%(HPLC) | CAS Number | 519055-62-0 |
Formula | C11H6BrCl2NO3S2 | Molecular Weight | 415.11 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | ≥50mg/ml |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Tasisulam is an acyl-sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
