l General Information |
Product Name | Tezacaftor |
General description | Tezacaftor is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2. |
Synonym | VX-661 |
Purity | ≥98.5%(HPLC) | CAS Number | 1152311-62-0 |
Formula | C26H27F3N2O6 | Molecular Weight | 520.5 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | Insoluble |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Tezacaftor is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor; a CFTR potentiator that allows the proteins at the cell surface to open longer and improve nutrient transport. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
