l General Information |
Product Name | GDC-0152 |
General description | GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. |
Synonym | (2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide |
Purity | ≥98.5%(HPLC) | CAS Number | 873652-48-3 |
Formula | C25H34N6O3S | Molecular Weight | 498.64 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | ≥50mg/ml |
Water | Insoluble |
l Biological Information |
Biochem/Physiol
Actions | GDC-0152 has been used in trials studying the treatment of Solid Cancers. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
