Product Name

Delapril Hydrochloride

General description

Delapril Hydrochloride is an agonist of the RXR signaling pathway.

Synonym

2-[2,3-dihydro-1H-inden-2-yl-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]amino]acetic acid; hydrochloride

Purity

≥97.0%(HPLC)

CAS Number

83435-67-0

Formula

C²⁶H³³ClN²O⁵

Molecular Weight

489.00362

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥50mg/ml

Ethanol

≥15mg/ml

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Delapril Hydrochloride is the hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delaprilalso decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodiumexcretion and subsequently increases water outflow.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov