Product Name

Clodronate disodium tetrahydrate

General description

Clodronate is a non-nitrogenous bisphosphonate that can bind to bone to reduce the bone resorption. It is used as an anti-osteoporotic drug for the prevention of osteoporosis in post-menopausal women and men.

Synonym

Disodium Clodronate Tetrahydrate; Clodronate Disodium Tetrahydrate

Purity

≥98.0%(T)

CAS Number

88416-50-6

Formula

CH¹⁰Cl²Na²O¹⁰P²

Molecular Weight

360.917162

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

Very slightly soluble

Water

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Clodronate Disodium is the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov