l General Information |
Product Name | Cilastatin |
General description | Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. |
Synonym | Cilastatinum; Cilastatine; Cilastatina; Cilastatin Acid; Cilastatine |
Purity | ≥98.5%(HPLC) | CAS Number | 82009-34-5 |
Formula | C16H26N2O5S | Molecular Weight | 358.45304 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | Insoluble |
Water | ~5mg/ml |
l Biological Information |
Biochem/Physiol
Actions | A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
