l General Information |
Product Name | Cytarabine hydrochloride |
General description | Cytarabine hydrochloride is a pyrimidine nucleoside analog that is used mainly in the treatment of leukemia. It is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. |
Synonym | Cytosine Arabinoside Hydrochloride |
Purity | ≥99.0%(HPLC) | CAS Number | 69-74-9 |
Formula | C9H14ClN3O5 | Molecular Weight | 279.68 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White Solid |
Solubility(25°C) | DMSO | ≥45mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Cytarabine Hydrochloride is the hydrochloride form of cytarabine, an antimetabolite analogue of cytidine with a modified sugar moiety (arabinose instead of ribose). Cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. This agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
