Product Name

Tobramycin sulfate

General description

ipid Storage Modulator

Synonym

Tobryne; Tomycin; Tobrasix; Nebcine

Purity

≥98.0%(TLC)

CAS Number

49842-07-1

Formula

C³⁶H⁸⁴N¹⁰O³⁸S⁵

Molecular Weight

1425.42

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

Very slightly soluble

Water

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA.

Tobramycin sulfate is an aminoglycoside.

Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.

Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov