Product Name

Amodiaquine hydrochloride

General description

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine with antimalarial and anti-inflammatory properties.

Synonym

Amodiaquin Dihydrochloride; 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol; dihydrochloride 

Purity

≥98.0%(HPLC)

CAS Number

69-44-3

Formula

C²⁰H²⁴Cl³N³O

Molecular Weight

428.78

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥45mg/ml

l  Biological Information

Biochem/Physiol  Actions

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov