Product Name

Desipramine Hydrochloride

General description

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.

Synonym

Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901

Purity

≥98.0%(HPLC)

CAS Number

58-28-6

Formula

C¹⁸H²³ClN²

Molecular Weight

302.84

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Off White Solid

Solubility(25°C)

DMSO

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Desipramine Hydrochloride is the hydrochloride salt form of desipramine, a secondary amine tricyclic antidepressant (TCA). In the central nervous system (CNS), desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov