Product Name

Rimantadine Hydrochloride

General description

Rimantadine Hydrochloride is an RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza. It works by inhibiting a viral protein called M2, which normally mediates the transport of acid ions across the influenza virion shell.

Synonym

Flumadine; Meradane; 1-(1-Aminoethyl)Adamantane Hydrochloride; 1-(1-adamantyl)ethanamine;hydrochloride   

Purity

≥99.0%(with Total Nitrogen)

CAS Number

1501-84-4

Formula

C¹²H²²ClN

Molecular Weight

215.76

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Off White Solid

Solubility(25°C)

DMSO

≥35mg/ml

l  Biological Information

Biochem/Physiol  Actions

Rimantadine Hydrochloride is the hydrochloride salt form of rimantadine, a cyclic amine and alpha-methyl derivative of amantadine with antiviral activity. Although the exact mechanism of action of rimantadine is not understood, this agent appears to exert its antiviral effect against influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the uncoating of the virus and subsequent release of infectious viral nucleic acids into the cytoplasm of infected cells.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov