Product Name

Arformoterol Tartrate

General description

Formoterol tartrate is a salt form of Formoterol. Formoterol is a beta 2 adrenergic receptor agonist that can be used in the treatment of asthma and COPD. It has an extended duration of action (up to 12 hours) compared to short-acting β2 agonists such as salbutamol (4–6 hours). Formoterol can be used as "symptom controllers" to supplement prophylactic corticosteroid therapy.

Synonym

(R,R)-Formoterol Tartrate

Purity

≥98.0%(HPLC)

CAS Number

200815-49-2

Formula

C²³H³⁰N²O¹⁰

Molecular Weight

494.4917

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to Beige Solid

Solubility(25°C)

DMSO

≥50mg/ml

l  Biological Information

Biochem/Physiol  Actions

Arformoterol Tartrate is the tartrate salt of arformoterol, the (R,R)-enantiomer of formoterol and a long-acting beta-2 adrenergic agonist with bronchodilator activity. Arformoterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP)  to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle and lead to an inhibition of release of inflammatory mediators from mast cells. This may eventually lead to an improvement of airway function.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov