l General Information |
Product Name | Calcium folinate |
General description | Calcium folinate is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives. |
Synonym | Leucovorin calcium, Folinic acid calcium salt |
Purity | ≥99.0%(HPLC) | CAS Number | 1492-18-8 |
Formula | C20H21CaN7O7 | Molecular Weight | 511.5 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Yellow to Orange Solid |
Solubility(25°C) | DMSO | Very slightly soluble |
Water | ≥50mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Leucovorin Calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
