l General Information |
Product Name | Acotiamide |
General description | Acotiamide is a novel acetylcholinesterase inhibitor with fundus-relaxing and gastroprokinetic properties. |
Synonym | Acofide; N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide |
Purity | ≥98.0%(HPLC) | CAS Number | 185106-16-5 |
Formula | C21H30N4O5S | Molecular Weight | 450.55 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to beige Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | ≥25mg/ml |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Acotiamide is a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
