l General Information |
Product Name | Argatroban Monohydrate |
General description | Argatroban is a direct, selective thrombin inhibitor with anticoagulant effects. |
Synonym | Argatroban hydrate, Argipidine |
Purity | ≥99.0%(HPLC) | CAS Number | 141396-28-3 |
Formula | C23H38N6O6S | Molecular Weight | 526.65 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | White to off-white Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | ≥35mg/ml |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | Argatroban is a synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site thereby preventing the thrombin-dependent reactions, which include conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots and coagulation is inhibited. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
