Product Name

Ganciclovir sodium

General description

Ganciclovir sodium is an antiviral medication used to treat cytomegalovirus (CMV) infections

Synonym

Natclovir; Cytovene IV; Ganciclovir Sodium Salt; sodium; 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate

Purity

≥99.0%(HPLC)

CAS Number

107910-75-8

Formula

C⁹H¹²N⁵NaO⁴

Molecular Weight

277.21

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

Insoluble

Ethanol

Insoluble

Water

≥45mg/ml

l  Biological Information

Biochem/Physiol  Actions

Ganciclovir Sodium is the sodium salt form of ganciclovir, a synthetic, antiviral, purine nucleoside analog with antiviral activity, especially against cytomegalovirus (CMV). Ganciclovir sodium is a prodrug that is phosphorylated and subsequently converted into its triphosphate form, the active metabolite ganciclovir-5-triphosphate (ganciclovir-TP), in the infected cells by cellular kinases. Ganciclovir-TP competes as a substrate with nucleotide triphosphates for viral DNA polymerase. Once it gets incorporated into DNA strand, it prevents further polymerization of DNA, thereby interfering with viral DNA replication.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov