l General Information |
Product Name | Pixantrone Maleate |
General description | Pixantrone is a novel aza-anthracenedione compound with antitumor activity. It is a weak topoisomerase II inhibitor and forms stable DNA adducts through alkylation with specificity for DNA hypermethylated sites. |
Synonym | BBR-2778; 6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione; (Z)-but-2-enedioic acid |
Purity | ≥99.0%(HPLC) | CAS Number | 144675-97-8 |
Formula | C25H27N5O10 | Molecular Weight | 557.51 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Purple to Dark Blue Solid |
Solubility(25°C) | DMSO | ≥50mg/ml |
Ethanol | Insoluble |
Water | ≥50mg/ml |
l Biological Information |
Biochem/Physiol
Actions | Pixantrone Dimaleate is the dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosss, resulting in inhibition of DNA replication and tumor cell cytotoxicity. |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
