Product Name

Revaprazan Hydrochloride

General description

Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects.

Synonym

YH1885; N-(4-fluorophenyl)-4,5-dimethyl-6-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)pyrimidin-2-amine; hydrochloride 

Purity

≥99.0%(HPLC)

CAS Number

178307-42-1

Formula

C²²H²⁴ClFN⁴

Molecular Weight

398.9

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥5mg/ml

l  Biological Information

Biochem/Physiol  Actions

Revaprazan Hydrochloride is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. Revaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H₊/K₊ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H₊ ions into the gastric lumen, the final step in gastric acid production.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov