7–Ethyl–10–hydroxycamptothecin (SN-38)
Product #：
TS2257
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TS2257-25MG
In-stock
36
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TS2257-100MG
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76
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TS2257-500MG
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190
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Details
l General Information |
Product Name | 7–Ethyl–10–hydroxycamptothecin |
General description | 7–Ethyl–10–hydroxycamptothecin is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. |
Synonym | SN-38 |
Purity | ≥99.0%(HPLC) | CAS Number | 86639-52-3 |
Formula | C22H20N2O5 | Molecular Weight | 392.4 |
Suitability | BioReagent, suitable for cell culture, etc. |
l Physical and Chemical Information |
Appearance | Off-White to Yellow Solid |
Solubility(25°C) | DMSO | ≥25mg/ml |
Ethanol | Insoluble |
Water | Very slightly soluble |
l Biological Information |
Biochem/Physiol
Actions | A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS. |
Application | Topoisomerase I Inhibitors |
l Storage |
Storage temp. | -20°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
