Product Name

Perphenazine

General description

Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.

Synonym

Perphenazine, Perphenazin, Trilafon, Etaperazine; 2-[4-[3-(2-chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol

Purity

≥99.0%(HPLC)

CAS Number

58-39-9

Formula

C²¹H²⁶ClN³OS

Molecular Weight

403.97

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to off-white Solid

Solubility(25°C)

DMSO

≥45mg/ml

Ethanol

≥45mg/ml

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as  hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov