Product Name

Amodiaquine dihydrochloride dihydrate

General description

Amodiaquine dihydrochloride is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It  is also used as an antimalarial and anti-inflammatory agent.

Synonym

Amodiaquine HCl; 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol; dihydrate; dihydrochloride

Purity

≥98.0%(HPLC)

CAS Number

6398-98-7

Formula

C²⁰H²⁸Cl³N³O³

Molecular Weight

464.81

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

≥45mg/ml

Ethanol

Insoluble

Water

≥5mg/ml

l  Biological Information

Biochem/Physiol  Actions

Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. Similar in structure and activity to chloroquine, amodiaquine is effective against some chloroquine-resistant strains, particularly Plasmodium falciparum, the most deadly malaria parasite. Although the mechanism of plasmodicidal action has not been fully elucidated, like other quinoline derivatives, amodiaquine likely is able to inhibit heme polymerase activity in the body. This results in accumulation of free heme, which is toxic to the parasites.

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov