Product Name

Azelaic acid

General description

Azelaic acid is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.

Synonym

Nonanedioic acid, Finacea, Azelex, Anchoic acid; nonanedioic acid

Purity

≥98.0%(GC)

CAS Number

123-99-9

Formula

C⁹H¹⁶O⁴

Molecular Weight

188.223

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

White to yellow Solid

Solubility(25°C)

DMSO

≥25mg/ml

Water

≥25mg/ml

l  Biological Information

Biochem/Physiol  Actions

Azelaic Acid is a naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygenradical. This drug is used topically to reduce inflammation associated with acne and rosacea.

Application

1.Antineoplastic Agents

2.Dermatologic Agents

l  Storage

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov