Product Name

Trihexyphenidyl hydrochloride

General description

Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.

Synonym

Benzhexol hydrochloride, Artane hydrochloride; 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol; hydrochloride

Purity

≥99.0%(HPLC)

CAS Number

52-49-3

Formula

C²⁰H³²ClNO

Molecular Weight

337.932

Suitability

BioReagent, suitable for cell culture, etc.

l  Physical and Chemical Information

Appearance

Solid

Solubility(25°C)

DMSO

~5mg/ml

Water

Very slightly soluble

l  Biological Information

Biochem/Physiol  Actions

Trihexyphenidyl Hydrochloride is the  hydrochloride salt form of trihexyphenidyl, a synthetic, substituted piperidine with parasympatholytic activity used mostly in Parkinson's disease. Trihexyphenidyl hydrochloride antagonizes activities of acetylcholine via muscarinic receptors. This balances the cholinergic and dopaminergic activity in the basal ganglia leading to an improvement of classic Parkinson symptoms such as rigidity and tremor. In addition, trihexyphenidyl hydrochloride exerts a direct antispasmodic effect on smooth muscle.

Application

1.Antiparkinson Agents

2.Muscarinic Antagonists

l  Storagel

Storage temp.

-20°C

l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov